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Molecular & Cellular Proteomics 1:763-780, 2002.
© 2002 by The American Society for Biochemistry and Molecular Biology, Inc.

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Report

Defining the Mandate of Proteomics in the Post-Genomics Era: Workshop Report

©2002 National Academy of Sciences, Washington, D.C., USA. Reprinted with permission from the National Academies Press for the National Academy of Sciences. All rights reserved. The original report may be viewed online at http://www.nap.edu/catalog/10209.html

^a College of Pharmacy, University of Michigan, Ann Arbor, MI 48109-1065
^b U.S. Environmental Protection Agency, Research Triangle Park, NC 27711
^c The Rockefeller University, New York, NY 10021
^d Keck Graduate Institute of Applied Life Sciences, Claremont, CA 91711
^e Department of Molecular and Cellular Biology, University of California-Berkeley, Berkeley, CA 94720-3206
^f Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461-1975
^g MitoKor, San Diego, CA 92121
^h Department of Chemistry and Biochemistry, Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA 02254-9110
ⁱ W.M. Keck Institute for Cellular Visualization, Rosensteil Basic Medical Sciences Research Center, Brandeis University, Waltham, MA 02254-9110
^j Howard Hughes Medical Institute, Chevy Chase, MD 20815-6789
^k Program Officer, Board on International Scientific Organizations, Policy and Global Affairs, The National Academies, Washington, D.C. 20418

Research in proteomics is the next step after genomics in understanding life processes at the molecular level. In the largest sense proteomics encompasses knowledge of the structure, function and expression of all proteins in the biochemical or biological contexts of all organisms. Since that is an impossible goal to achieve, at least in our lifetimes, it is appropriate to set more realistic, achievable goals for the field. Up to now, primarily for reasons of feasibility, scientists have tended to concentrate on accumulating information about the nature of proteins and their absolute and relative levels of expression in cells (the primary tools for this have been 2D gel electrophoresis and mass spectrometry). Although these data have been useful and will continue to be so, the information inherent in the broader definition of proteomics must also be obtained if the true promise of the growing field is to be realized. Acquiring this knowledge is the challenge for researchers in proteomics and the means to support these endeavors need to be provided. An attempt has been made to present the major issues confronting the field of proteomics and two clear messages come through in this report. The first is that the mandate of proteomics is and should be much broader than is frequently recognized. The second is that proteomics is much more complicated than sequencing genomes. This will require new technologies but it is highly likely that many of these will be developed. Looking back 10 to 20 years from now, the question is: Will we have done the job wisely or wastefully? This report summarizes the presentations made at a symposium at the National Academy of Sciences on February 25, 2002.

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