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Originally published In Press as doi:10.1074/mcp.M200001-MCP200 on April 2, 2002.
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Molecular & Cellular Proteomics 1:323-333, 2002.
© 2002 by The American Society for Biochemistry and Molecular Biology, Inc.

Research

Complementary Profiling of Gene Expression at the Transcriptome and Proteome Levels in Saccharomyces cerevisiae*,S

Timothy J. Griffin{ddagger}, Steven P. Gygi§, Trey Ideker, Beate Rist||, Jimmy Eng, Leroy Hood and Ruedi Aebersold**

From the Institute for Systems Biology, Seattle, Washington 98103

Using an integrated genomic and proteomic approach, we have investigated the effects of carbon source perturbation on steady-state gene expression in the yeast Saccharomyces cerevisiae growing on either galactose or ethanol. For many genes, significant differences between the abundance ratio of the messenger RNA transcript and the corresponding protein product were observed. Insights into the perturbative effects on genes involved in respiration, energy generation, and protein synthesis were obtained that would not have been apparent from measurements made at either the messenger RNA or protein level alone, illustrating the power of integrating different types of data obtained from the same sample for the comprehensive characterization of biological systems and processes.

** To whom correspondence should be addressed: Inst. for Systems Biology, 1441 N. 34th St., Seattle, WA 98103. Tel.: 206-732-1204; Fax: 206-732-1255; E-mail: raebersold{at}systemsbiology.org


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