MCP Waters-The Science of What's Possible
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Originally published In Press as doi:10.1074/mcp.M300053-MCP200 on August 19, 2003.
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Molecular & Cellular Proteomics 2:1104-1119, 2003.
© 2003 by The American Society for Biochemistry and Molecular Biology, Inc.

Research

ERp19 and ERp46, New Members of the Thioredoxin Family of Endoplasmic Reticulum Proteins*

Barbara Knoblach{ddagger}, Bernd O. Keller§, Jody Groenendyk{ddagger},¶, Sandi Aldred{ddagger}, Jing Zheng§, Bernard D. Lemire{ddagger}, Liang Li§ and Marek Michalak{ddagger},||

From the {ddagger} Canadian Institutes of Health Research Membrane Protein Research Group and the Departments of Biochemistry and § Chemistry, University of Alberta, Edmonton, Alberta, Canada T6G 2H7

Using a proteomic analysis of the luminal environment of the endoplasmic reticulum (ER), we have identified 141 proteins, of which 6 were previously unknown. Two newly discovered ER luminal proteins, designated ERp19 and ERp46, are related to protein disulphide isomerase. Western and Northern blot analyses revealed that both ERp19 and ERp46 and their respective mRNAs are highly expressed in the liver as compared with other tissues. Both proteins were enriched in purified liver ER vesicles and were localized specifically to the ER in McA-RH7777 hepatocytes. Functional analysis with yeast complementation studies showed that ERp46 but not ERp19 can substitute for protein disulphide isomerase function in vivo.

|| Canadian Institutes of Health Research Senior Investigator and Alberta Heritage Foundation for Medical Research Medical Scientist. To whom correspondence should be addressed. Tel.: 780-492-2256; Fax: 780-492-0886; E-mail: Marek.Michalak{at}ualberta.ca


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