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Originally published In Press as doi:10.1074/mcp.R300003-MCP200 on May 29, 2003.
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Molecular & Cellular Proteomics 2:281-291, 2003.
© 2003 by The American Society for Biochemistry and Molecular Biology, Inc.

Review

Breast Cancer

When Proteomics Challenges Biological Complexity*

Hubert Hondermarck{ddagger}

From the UPRES-EA 1033, IFR-118 Proteomics, Post-translational Modifications, and Glycobiology, University of Sciences and Technologies, Lille, 59650 Villeneuve d’Ascq Cedex, France

Proteomics is now entering into the field of biomedicine with declared hopes for the identification of new pathological markers and therapeutic targets. Current proteomic tools allow large-scale, high-throughput analyses for the detection, identification, and functional investigation of low-abundant proteins. However, the major limitation of proteomic investigations remains the complexity of biological structures and physiological processes, rendering the path of exploration of related pathologies paved with various difficulties and pitfalls. The case of breast cancer illustrates the major challenge facing modern proteomics and more generally post-genomics: to tackle the complexity of life.

{ddagger} To whom correspondence should be addressed: UPRES-EA 1033, Batiment SN3, Université Lille 1, 59650 Villeneuve d’Ascq Cedex, France. Tel.: 33-3-20-43-40-97; Fax: 33-3-20-43-40-38; E-mail: hubert.hondermarck{at}univ-lille1.fr


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