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Molecular & Cellular Proteomics 2:369-377, 2003.
© 2003 by The American Society for Biochemistry and Molecular Biology, Inc.

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Review

Integrating Proteomic and Functional Genomic Technologies in Discovery-driven Translational Breast Cancer Research^*

Julio E. Celis^a,b,, Pavel Gromov^a,b, Irina Gromova^a,b, José M. A. Moreira^a,b, Teresa Cabezón^a,b, Noona Ambartsumian^a,c, Mariam Grigorian^a,c, Eugene Lukanidin^a,c, Per thor Straten^a,d, Per Guldberg^a,e, Jirina Bartkova^a,f, Jiri Bartek^a,f, Jiri Lukas^a,f, Claudia Lukas^a,f, Anne Lykkesfeldt^a,g, Marja Jäättelä^a,h, Peter Roepstorff^a,i, Lars Bolund^a,j, Torben Ørntoft^a,k, Nils Brünner^a,l, Jens Overgaard^a,m, Kerstin Sandelin^a,n, Mogens Blichert-Toft^a,o, Henning Mouridsen^a,p and Fritz E. Rank^a,q

From ^a The Danish Centre for Translational Breast Cancer Research, Strandboulevarden 49, DK-2100 Copenhagen, Denmark, ^b Department of Proteomics in Cancer, Institute of Cancer Biology, The Danish Cancer Society, Strandboulevarden 49, DK-2100 Copenhagen, Denmark, ^c Department of Molecular Cancer Biology, Institute of Cancer Biology, The Danish Cancer Society, Strandboulevarden 49, DK-2100 Copenhagen, Denmark, ^d Tumor Immunology Group, Institute of Cancer Biology, The Danish Cancer Society, Strandboulevarden 49, DK-2100 Copenhagen, Denmark, ^e Laboratory of Cancer Genomics, Institute of Cancer Biology, The Danish Cancer Society, Strandboulevarden 49, DK-2100 Copenhagen, Denmark, ^f Department of Cell Cycle and Cancer, Institute of Cancer Biology, The Danish Cancer Society, Strandboulevarden 49, DK-2100 Copenhagen, Denmark, ^g Department of Tumor Endocrinology, Institute of Cancer Biology, The Danish Cancer Society, Strandboulevarden 49, DK-2100 Copenhagen, Denmark, ^h Department of Apoptosis, Institute of Cancer Biology, The Danish Cancer Society, Strandboulevarden 49, DK-2100 Copenhagen, Denmark, ⁱ Department of Biochemistry and Molecular Biology, Danish Biotechnology Instrument Centre, University of Southern Denmark, Campusvej 55, DK-5230 Odense, Denmark, ^j Department of Human Genetics, Aarhus University, Nordre Ringgade 1, DK-8000 Aarhus, Denmark, ^k Department of Clinical Biochemistry, Aarhus University, Nordre Ringgade 1, DK-8000 Aarhus, Denmark, ^l Department of Pharmacology and Pathobiology, Royal Veterinary and Agricultural University, Rolighedsvej 30, DK-1958 Frederiksberg, Denmark, ^m Department of Experimental Clinical Oncology, Aarhus University Hospital, Nørrebrogade 44, DK-8000 Aarhus, Denmark, ⁿ Department of Breast and Endocrine Surgery, Copenhagen University Hospital, Blegdamsvej 9, DK-2100 Copenhagen, Denmark, ^o Danish Breast Cancer Cooperative Group, Copenhagen University Hospital, Blegdamsvej 9, DK-2100 Copenhagen, Denmark, ^p Department of Oncology, Copenhagen University Hospital, Blegdamsvej 9, DK-2100 Copenhagen, Denmark, and ^q Department of Pathology, The Centre of Diagnostic Investigations, Copenhagen University Hospital, Blegdamsvej 9, DK-2100 Copenhagen, Denmark

The application of state-of-the-art proteomics and functional genomics technologies to the study of cancer is rapidly shifting toward the analysis of clinically relevant samples derived from patients, as the ultimate aim of translational research is to bring basic discoveries closer to the bedside. Here we describe the essence of a long-term initiative undertaken by The Danish Centre for Translational Breast Cancer Research and currently underway for cancer biomarker discovery using fresh tissue biopsies and bio-fluids. The Centre is a virtual hub that brings together scientists working in various areas of basic cancer research such as cell cycle control, invasion and micro-environmental alterations, apoptosis, cell signaling, and immunology, with clinicians (oncologists, surgeons), pathologists, and epidemiologists, with the aim of understanding the molecular mechanisms underlying breast cancer progression and ultimately of improving patient survival and quality of life. The unifying concept behind our approach is the use of various experimental paradigms for the prospective analysis of clinically relevant samples obtained from the same patient, along with the systematic integration of the biological and clinical data.

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