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Originally published In Press as doi:10.1074/mcp.M400085-MCP200 on September 2, 2004.
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Molecular & Cellular Proteomics 3:1093-1101, 2004.
© 2004 by The American Society for Biochemistry and Molecular Biology, Inc.

Research

Phosphoproteomic Analysis of the Developing Mouse Brain*,S

Bryan A. Ballif, Judit Villén, Sean A. Beausoleil, Daniel Schwartz and Steven P. Gygi{ddagger}

From the Department of Cell Biology, Harvard Medical School, Boston, MA 02115

Proper development of the mammalian brain requires the precise integration of numerous temporally and spatially regulated stimuli. Many of these signals transduce their cues via the reversible phosphorylation of downstream effector molecules. Neuronal stimuli acting in concert have the potential of generating enormous arrays of regulatory phosphoproteins. Toward the global profiling of phosphoproteins in the developing brain, we report here the use of a mass spectrometry-based methodology permitting the first proteomic-scale phosphorylation site analysis of primary animal tissue, identifying over 500 protein phosphorylation sites in the developing mouse brain.

{ddagger} To whom correspondence should be addressed: Department of Cell Biology, Harvard Medical School, Boston, MA 02115. Tel.: 617-432-3155; Fax: 617-432-1144; E-mail: steven_gygi{at}hms.harvard.edu


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