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Originally published In Press as doi:10.1074/mcp.R400007-MCP200 on February 28, 2004.
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Molecular & Cellular Proteomics 3:367-378, 2004.
© 2004 by The American Society for Biochemistry and Molecular Biology, Inc.

Review

Mass Spectrometry as a Diagnostic and a Cancer Biomarker Discovery Tool

Opportunities and Potential Limitations*

Eleftherios P. Diamandis{ddagger}

From the Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada

Serum proteomic profiling, by using surfaced-enhanced laser desorption/ionization-time-of-flight mass spectrometry, is one of the most promising new approaches for cancer diagnostics. Exceptional sensitivities and specificities have been reported for some cancer types such as prostate, ovarian, breast, and bladder cancers. These sensitivities/specificities are far superior to those obtained by using classical cancer biomarkers. In this review, I concentrate more on questions that cast doubt on the results reported and propose experiments to investigate these questions in detail, before the technique is used at the clinic. It is clear that the method needs to be externally and thoroughly validated before clinical implementation is warranted.

{ddagger} To whom correspondence should be addressed: Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada. Tel.: 416-586-8443; Fax: 416-586-8628; E-mail: ediamandis{at}mtsinai.on.ca


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