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Originally published In Press as doi:10.1074/mcp.R500013-MCP200 on August 23, 2005.
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Molecular & Cellular Proteomics 4:1841-1848, 2005.
© 2005 by The American Society for Biochemistry and Molecular Biology, Inc.

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Human Liver Proteome Project

Plan, Progress, and Perspectives*

Fuchu He{ddagger}

From the Beijing (National) Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 100850, China and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China

The Human Liver Proteome Project is the first initiative of the human proteome project for human organs/tissues and aims at writing a modern Prometheus myth. Its global scientific objectives are to reveal the "solar system" of the human liver proteome, expression profiles, modification profiles, a protein linkage (protein-protein interaction) map, and a proteome localization map, and to define an ORFeome, physiome, and pathome. Since it was first proposed in April 2002, the Human Liver Proteome Project has attracted more than 100 laboratories from all over the world. In the ensuing 3 years, we set up a management infrastructure, identified reference laboratories, confirmed standard operating procedures, initiated international research collaborations, and finally achieved the first set of expression profile data.

{ddagger} On behalf of the Human Proteome Organization (HUPO) Human Liver Proteome Project Consortium. To whom correspondence should be addressed: Beijing Inst. of Radiation Medicine, 27 Taiping Road, Beijing 100850, China. Tel. and Fax: 8610-68177417; E-mail: hefc{at}nic.bmi.ac.cn or gaox{at}hupo.org.cn


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