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Originally published In Press as doi:10.1074/mcp.M500006-MCP200 on January 31, 2005.
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Molecular & Cellular Proteomics 4:409-418, 2005.
© 2005 by The American Society for Biochemistry and Molecular Biology, Inc.

Research

Biomarkers: Mining the Biofluid Proteome*

Timothy D. Veenstra{ddagger},§, Thomas P. Conrads{ddagger}, Brian L. Hood{ddagger}, Anthony M. Avellino, Richard G. Ellenbogen and Richard S. Morrison

From the {ddagger} Laboratory of Proteomics and Analytical Technologies, SAIC-Frederick, Inc., National Cancer Institute at Frederick, Frederick, MD 21702-1201
Department of Neurological Surgery, University of Washington School of Medicine, Seattle, WA 98195

Proteomics has brought with it the hope of identifying novel biomarkers for diseases such as cancer. This hope is built on the ability of proteomic technologies, such as mass spectrometry (MS), to identify hundreds of proteins in complex biofluids such as plasma and serum. There are many factors that make this research very challenging beginning with the lack of standardization of sample collection and continuing through the entire analytical process. Fortunately the advances made in the characterization of biofluids using proteomic techniques have been rapid and suggest that these mainly discovery driven approaches will lead to the development of highly specific platforms for diagnosing diseases and monitoring responses to different treatments in the near future.

§ To whom correspondence should be addressed: SAIC-Frederick, Inc., National Cancer Institute at Frederick, P.O. Box B, Bldg. 469, Rm. 160, Frederick, MD 21702. Tel.: 301-846-7286; Fax: 301-846-6037; E-mail:veenstra{at}ncifcrf.gov


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