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Originally published In Press as doi:10.1074/mcp.R500004-MCP200 on January 31, 2005.
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Molecular & Cellular Proteomics 4:523-533, 2005.
© 2005 by The American Society for Biochemistry and Molecular Biology, Inc.

Review

Proteomic Profiling of Pancreatic Cancer for Biomarker Discovery*

Ru Chen{ddagger}, Sheng Pan§, Teresa A. Brentnall{ddagger},¶ and Ruedi Aebersold§,||

From the {ddagger} GI Division/Department of Medicine, University of Washington, Seattle, WA 98195; § Institute for Systems Biology, Seattle, WA 98103; and || Institute for Molecular Systems Biology, ETH Zurich and Faculty of Nature, Science Federal Institute, University of Zurich, CH-8093 Zurich, Switzerland

Pancreatic cancer is a uniformly lethal disease that is difficult to diagnose at early stage and even more difficult to cure. In recent years, there has been a substantial interest in applying proteomics technologies to identify protein biomarkers for early detection of cancer. Quantitative proteomic profiling of body fluids, tissues, or other biological samples to identify differentially expressed proteins represents a very promising approach for improving the outcome of this disease. Proteins associated with pancreatic cancer identified through proteomic profiling technologies could be useful as biomarkers for the early diagnosis, therapeutic targets, and disease response markers. In this article, we discuss recent progress and challenges for applying quantitative proteomics technologies for biomarker discovery in pancreatic cancer.

To whom correspondence should be addressed: Department of Medicine, Division of Gastroenterology, University of Washington, Seattle, WA 98195. Tel.: 206-543-3280; Fax: 206-685-9478; E-mail: teribr{at}u.washington.edu


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