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Molecular & Cellular Proteomics 4:1350-1357, 2005.
© 2005 by The American Society for Biochemistry and Molecular Biology, Inc.

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Research

Analysis of Intimal Proteoglycans in Atherosclerosis-prone and Atherosclerosis-resistant Human Arteries by Mass Spectrometry^*,S

Paul Talusan^,, Shahinaz Bedri, Suping Yang, Taj Kattapuram, Nilsa Silva, Peter J. Roughley^¶ and James R. Stone^,||

From the Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, Division of Graduate Medical Sciences, Boston University School of Medicine, Boston, Massachusetts 02118, ^¶ Genetics Unit, Shriners Hospital for Children, and Department for Surgical Research, Department of Surgery, McGill University, Montreal, Quebec H3G 1A6, Canada

The propensity to develop atherosclerosis varies markedly among different sites in the human vasculature. To determine a possible cause for such differences in atherosclerosis susceptibility, a proteomics-based approach was used to assess the extracellular proteoglycan core protein composition of intimal hyperplasia from both the atherosclerosis-prone internal carotid artery and the atherosclerosis-resistant internal thoracic artery. The intimal proteoglycan composition in these preatherosclerotic lesions was found to be more complex than previously appreciated with up to eight distinct core proteins present, including the large extracellular proteoglycans versican and aggrecan, the basement membrane proteoglycan perlecan, the class I small leucine-rich proteoglycans biglycan and decorin, and the class II small leucine-rich proteoglycans lumican, fibromodulin, and prolargin/PRELP (proline arginine-rich end leucine-rich repeat protein). Although most of these proteoglycans seem to be present in similar amounts at the two locations, there was a selective enhanced deposition of lumican in the intima of the atherosclerosis-prone internal carotid artery compared with the intima of the atherosclerosis-resistant internal thoracic artery. The enhanced deposition of lumican in the intima of an atherosclerosis prone artery has important implications for the pathogenesis of atherosclerosis.

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