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Originally published In Press as doi:10.1074/mcp.R600011-MCP200 on May 29, 2006.
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Molecular & Cellular Proteomics 5:1772-1786, 2006.
© 2006 by The American Society for Biochemistry and Molecular Biology, Inc.

Cancer

Proteomics of Breast Cancer

Principles and Potential Clinical Applications*

François Bertucci{ddagger},§,¶,||, Daniel Birnbaum{ddagger} and Anthony Goncalves§,¶,**

From the {ddagger} Centre de Recherche en Cancérologie de Marseille, Département d’Oncologie Moléculaire, Institut Paoli-Calmettes (IPC) and UMR599 INSERM, § Département d’Oncologie Médicale and ** Département de Pharmacologie Moléculaire, IPC, and Faculté de Médecine, Université de la Méditerranée, 13009 Marseille, France

Progresses in screening, early diagnosis, prediction of aggressiveness and of therapeutic response or toxicity, and identification of new targets for therapeutic will improve survival of breast cancer. These progresses will likely be accelerated by the new proteomic techniques. In this review, we describe the different techniques currently applied to clinical samples of breast cancer and the most important results obtained with the two most popular proteomic approaches in translational research (tissue microarrays and SELDI-TOF).

|| To whom correspondence should be addressed: Dépt. d’Oncologie Moléculaire, Inst. Paoli-Calmettes, 232 Bd. Sainte-Marguerite, 13009 Marseille, France. Tel.: 33-4-91-22-35-37; Fax: 33-4-91-22-36-70; E-mail: bertuccif{at}marseille.fnclcc.fr






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Copyright © 2006 by the American Society for Biochemistry and Molecular Biology.