Originally published In Press as doi:10.1074/mcp.R600011-MCP200 on May 29, 2006.
Molecular & Cellular Proteomics 5:1772-1786, 2006.
© 2006 by The American Society for Biochemistry and Molecular Biology, Inc.
Cancer
Proteomics of Breast Cancer
Principles and Potential Clinical Applications*
François Bertucci
,
,¶,||,
Daniel Birnbaum
and
Anthony Goncalves
,¶,**
From the
Centre de Recherche en Cancérologie de Marseille, Département dOncologie Moléculaire, Institut Paoli-Calmettes (IPC) and UMR599 INSERM,
Département dOncologie Médicale and ** Département de Pharmacologie Moléculaire, IPC, and ¶ Faculté de Médecine, Université de la Méditerranée, 13009 Marseille, France
Progresses in screening, early diagnosis, prediction of aggressiveness and of therapeutic response or toxicity, and identification of new targets for therapeutic will improve survival of breast cancer. These progresses will likely be accelerated by the new proteomic techniques. In this review, we describe the different techniques currently applied to clinical samples of breast cancer and the most important results obtained with the two most popular proteomic approaches in translational research (tissue microarrays and SELDI-TOF).
|| To whom correspondence should be addressed: Dépt. dOncologie Moléculaire, Inst. Paoli-Calmettes, 232 Bd. Sainte-Marguerite, 13009 Marseille, France. Tel.: 33-4-91-22-35-37; Fax: 33-4-91-22-36-70; E-mail: bertuccif{at}marseille.fnclcc.fr
Copyright © 2006 by the American Society for Biochemistry and Molecular Biology.