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Originally published In Press as doi:10.1074/mcp.M600088-MCP200 on June 14, 2006.
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Molecular & Cellular Proteomics 5:1914-1920, 2006.
© 2006 by The American Society for Biochemistry and Molecular Biology, Inc.

Other Diseases and Conditions

Protein Biomarkers in a Mouse Model of Extremes in Trait Anxiety*

Claudia Ditzen, Archana M. Jastorff, Melanie S. Kessler, Mirjam Bunck, Larysa Teplytska, Angelika Erhardt, Simone A. Krömer, Jeeva Varadarajulu, Bianca-Sabrina Targosz, Eser F. Sayan-Ayata, Florian Holsboer, Rainer Landgraf and Christoph W. Turck{ddagger}

From the Max Planck Institute of Psychiatry, D-80804 Munich, Germany

Brain proteome analysis of mice selectively bred for either high or low anxiety-related behavior revealed quantitative and qualitative protein expression differences. The enzyme glyoxalase-I was consistently expressed to a higher extent in low anxiety as compared with high anxiety mice in several brain areas. The same phenotype-dependent difference was also found in red blood cells with normal and cross-mated animals showing intermediate expression profiles of glyoxalase-I. Another protein that showed a different mobility during two-dimensional gel electrophoresis was identified as enolase phosphatase. The presence of both protein markers in red or white blood cells, respectively, creates the opportunity to screen for their expression in clinical blood specimens from patients suffering from anxiety.

{ddagger} To whom correspondence should be addressed: Max Planck Inst. of Psychiatry, Kraepelinstr. 2, D-80804 Munich, Germany. Tel.: 49-89-30622317; Fax: 49-89-30622200; E-mail: turck{at}mpipsykl.mpg.de


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