MCP Waters-The Science of What's Possible
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Originally published In Press as doi:10.1074/mcp.T600020-MCP200 on July 24, 2006.
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Molecular & Cellular Proteomics 5:1996-2007, 2006.
© 2006 by The American Society for Biochemistry and Molecular Biology, Inc.

Meeting Report

A Reagent Resource to Identify Proteins and Peptides of Interest for the Cancer Community

A WORKSHOP REPORT*

Brian B. Haaba,b, Amanda G. Paulovichb,c, N. Leigh Andersond,e, Adam M. Clarke,f, Gregory J. Downinge,f,g, Henning Hermjakobe,h, Joshua LaBaere,i and Mathias Uhlene,j

From the a Van Andel Research Institute, Grand Rapids, Michigan 49503, c Fred Hutchinson Cancer Research Center, Seattle, Washington 98109-1024, d Plasma Proteome Institute, Washington, D. C. 20009, f Office of Technology and Industrial Relations, NCI, National Institutes of Health, Bethesda, Maryland 20892, h European Molecular Biology Laboratory-European Bioinformatics Institute, Hinxton, Cambridge CB10 1SD, United Kingdom, i Harvard Institute of Proteomics, Harvard University, Cambridge, Massachusetts 02141-2023, and j Royal Institute of Technology, 106 91 Stockholm, Sweden

On the basis of discussions with representatives from all sectors of the cancer research community, the National Cancer Institute (NCI) recognizes the immense opportunities to apply proteomics technologies to further cancer research. Validated and well characterized affinity capture reagents (e.g. antibodies, aptamers, and affibodies) will play a key role in proteomics research platforms for the prevention, early detection, treatment, and monitoring of cancer. To discuss ways to develop new resources and optimize current opportunities in this area, the NCI convened the "Proteomic Technologies Reagents Resource Workshop" in Chicago, IL on December 12–13, 2005. The workshop brought together leading scientists in proteomics research to discuss model systems for evaluating and delivering resources for reagents to support MS and affinity capture platforms. Speakers discussed issues and identified action items related to an overall vision for and proposed models for a shared proteomics reagents resource, applications of affinity capture methods in cancer research, quality control and validation of affinity capture reagents, considerations for target selection, and construction of a reagents database. The meeting also featured presentations and discussion from leading private sector investigators on state-of-the-art technologies and capabilities to meet the user community’s needs. This workshop was developed as a component of the NCI’s Clinical Proteomics Technologies Initiative for Cancer, a coordinated initiative that includes the establishment of reagent resources for the scientific community. This workshop report explores various approaches to develop a framework that will most effectively fulfill the needs of the NCI and the cancer research community.

g To whom correspondence should be addressed: Office of Technology and Industrial Relations, Office of the Director, National Cancer Institute, Bldg. 31A, Rm. 11A-30, 31 Center Dr., Bethesda, MD 20892. Tel.: 301-496-1550; Fax: 301-496-7807; E-mail: downingg{at}mail.nih.gov


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