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Originally published In Press as doi:10.1074/mcp.M600336-MCP200 on January 21, 2007.
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Molecular & Cellular Proteomics 6:738-744, 2007.
© 2007 by The American Society for Biochemistry and Molecular Biology, Inc.

Research

Absence of Increased {alpha}1-Microglobulin in IgA Nephropathy Proteinuria*

Hiroyuki Yokota{ddagger},§, Masashi Hiramoto{ddagger}, Hirokazu Okada, Yoshihiko Kanno, Masatoshi Yuri{ddagger}, Shuji Morita{ddagger}, Masanori Naitou{ddagger}, Atsushi Ichikawa{ddagger}, Masao Katoh{ddagger} and Hiromichi Suzuki

From {ddagger} Astellas Pharm Inc., 21 Miyukigaoka, Tsukuba-shi 305-8585, Japan and the Department of Nephrology and Medical Education Center, School of Medicine, Faculty of Medicine, Saitama Medical University, 38 Morohongo, Moroyama, Iruma, Saitama 350-0495, Japan

To search for biomarkers of IgA nephropathy, protein profiles of urine samples from patients with IgA nephropathy and normal volunteers were compared using two-dimensional DIGE. Most of the 172 spots identified in the urine were serum proteins, and their amounts in IgA nephropathy urine were much higher than those in normal urine; this can be explained as proteinuria caused by glomerular dysfunction. However, only {alpha}1-microglobulin, also one of the major serum proteins, in IgA nephropathy urine was not higher in amount than that in normal urine. We confirmed using ELISA analysis that the amounts of transferrin and albumin in IgA nephropathy and diabetic nephropathy urine were much higher than those in normal urine, whereas the amount of {alpha}1-microglobulin in IgA nephropathy urine was not higher than that in normal urine and was much lower than that in diabetic nephropathy urine. Approximately 50% of {alpha}1-microglobulin forms a complex with IgA in serum. These results suggest that {alpha}1-microglobulin in IgA nephropathy urine is a characteristic protein and might be a biomarker for IgA nephropathy and that {alpha}1-microglobulin might have a relationship with IgA nephropathy pathology.

§ To whom correspondence should be addressed. Tel.: 81-29-852-5111; Fax: 81-29-852-5444; E-mail: hiroyuki.yokota{at}jp.astellas.com


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