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A more recent version of this article appeared on September 1, 2004.
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Submitted on March 31, 2004
Revised on May 11, 2004
Accepted on May 28, 2004

Identification and verification of novel rodent postsynaptic density proteins

Bryen A. Jordan, Brian D. Fernholz, Muriel Boussac, Chongfeng Xu, Gabriela Grigorean, Edward B. Ziff, and Thomas A. Neubert

New York University School of Medicine, New York, NY 10016

Corresponding Author: neubert{at}saturn.med.nyu.edu

The postsynaptic density (PSD) is a cellular structure specialized in receiving and transducing synaptic information. Here we describe the identification of 452 proteins isolated from biochemically purified PSD fractions of rat and mouse brains using nanoflow high performance liquid chromatography coupled to electrospray tandem mass spectrometry (LC-MS/MS). Fluorescence microscopy and Western blotting were used to verify that many of the novel proteins identified exhibit subcellular distributions consistent with those of PSD-localized proteins. In addition to identifying most previously described PSD components, we also detected proteins involved in signaling to the nucleus as well as regulators of ADP-ribosylation factor (ARF) signaling, ubiquitination, RNA trafficking, and protein translation. These results suggest new mechanisms by which the PSD helps regulate synaptic strength and transmission.


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