MCP Waters-The Science of What's Possible
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Submitted on January 6, 2005
Revised on January 31, 2005
Accepted on January 31, 2005

Biomarkers: Mining the biofluid proteome

Timothy D. Veenstra, Thomas P. Conrads, Brian L. Hood, Anthony M. Avellino, Richard G. Ellenbogen, and Richard S. Morrison

Mass Spectrometry Center, SAIC-Frederick Inc., NCI-Frederick, Frederick, MD 21702-1201

Corresponding Author: veenstra{at}ncifcrf.gov

ABSTRACT Proteomics has brought with it the hope of identifying no vel biomarkers for diseases such as cancer. This hope is built on the ability of proteomic technologies, such as mass spectrometry (MS), to identify hundreds of proteins in complex biofluids such as plasma and serum. There are many factors that make this research very challenging beginning with the lack of standardization of sample collection and continuing through the entire analytical process. Fortunately the advances made in the characterization of biofluids using proteomic techniques have been rapid and suggest that these mainly discovery driven approaches will lead to the development of highly specific platforms for diagnosing diseases and monitoring responses to different treatments in the near future.


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