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Submitted on January 14, 2005
Revised on January 31, 2005
Accepted on January 31, 2005

Proteomic profiling of pancreatic cancer for biomarker discovery

Ru Chen, Sheng Pan, Teresa A. Brentnall, and Ruedi Aebersold

Department of Medicine, University of Washington, Seattle, WA 98195

Corresponding Author: teribr{at}u.washington.edu

Pancreatic cancer is a uniformly lethal disease which is difficult to diagnose at early stage and even more difficult to cure. In recent years there has been a substantial interest in applying proteomics technologies to identify protein biomarkers for early detection of cancer. Quantitative proteomic profiling of body fluids, tissues or other biological samples to identify differentially expressed proteins represents a very promising approach for improving the outcome of this disease. Proteins associated with pancreatic cancer identified through proteomic profiling technologies could be useful as biomarkers for the early diagnosis, therapeutic targets, and disease response markers. In this paper, we discuss recent progress and challenges for applying quantitative proteomics technologies for biomarker discovery in pancreatic cancer.


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