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Submitted on June 27, 2005
Revised on August 23, 2005
Accepted on August 23, 2005

Human liver proteome project: Plan, progress and perspective

Fuchu He

Beijing Institute of Radiation Medicine, Beijing 100850

Corresponding Author: hefc{at}nic.bmi.ac.cn

The Human Liver Proteome Project (HLPP) is the first initiative of the human proteome project for human organs/tissues and aims at writing a modern Prometheus Myth. Its global scientific objectives are to reveal the “solar system” of the human liver proteome: expression profiles, modification profiles, a protein linkage (protein-protein interaction) map, a proteome localization map, and define an ORFeome, physiome and pathome. Since it was first proposed in April 2002, the HLPP has attracted more than 100 laboratories from all over the world. In the ensuing three years, we set up a management infrastructure, identified reference labs, confirmed standard operating procedures (SOPs), initiated international research collaborations and finally achieved the first set of expression profile data.


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