TABLE II Summary of the cytochrome P450 isoforms detected in the microsomal membrane fractions of lung and liver
| ID |
Liver |
Lung |
P450 isoform |
GO term |
Tissue specificitya |
|
| C2F2 |
 |
|
P450 2F2 |
Membrane |
Clara cells (lung and liver) |
| NCPR |
|
|
P450 reductase |
Membrane |
Liver microsomes |
| C39A |
|
|
P450 39A1 |
Membrane |
Liver microsomes |
| CP4B |
|
|
P450 4B1 |
Membrane |
Pulmonary microsomes (not found in liver) |
| CPBA |
|
|
P450 2B10 |
Membrane |
Liver microsomes |
| CP12 |
|
|
P450 1A2 |
Membrane |
Liver microsomes |
| CP3B |
|
|
P450 3A11 |
Membrane |
Liver microsomes |
| CP3G |
|
|
P450 3A16 |
Membrane |
Liver microsomes |
| CPAC |
|
|
P450 2A12 |
Membrane |
Liver microsomes |
| CPB9 |
|
|
P450 2B9 |
Membrane |
Liver microsomes |
| CPCT |
|
|
P450 2C29 |
Membrane |
Liver microsomes |
| CPD9 |
|
|
P450 2D9 |
Membrane |
Liver microsomes |
| CPDA |
|
|
P450 2D10 |
Membrane |
Liver microsomes |
| CPE1 |
|
|
P450 2E1 |
Membrane |
Highest level in liver |
| CPJ5 |
|
|
P450 2J5 |
Membrane |
Wide tissue distribution |
| CPT7 |
|
|
P450 17 |
Membrane |
No infomation |
| CPZ2 |
|
|
P450 2C37 |
Membrane |
Liver microsomes |
| CPZ3 |
|
|
P450 2C38 |
Membrane |
Liver, brain, kidney, and intestine (trace amounts in lung and heart) |
| CPZ4 |
|
|
P450 2C39 |
Membrane |
Liver microsomes |
| CPZ5 |
|
|
P450 2C40 |
Membrane |
Liver, brain, kidney, and intestine (trace amounts in lung and heart) |
| Q8VCX0 |
|
|
P450 2d9 |
N/Ab |
Liver microsomes |
| Q99N18 |
|
|
P450 CYP4F15 |
Monooxygenase |
High expression in liver and kidney, lower expression in brain |
| Q9DBW0 |
|
|
RIKEN: 1200012E24 |
Monooxygenase |
No information |
| Q9JKY7 |
|
|
P450 CYP2D22 |
Monooxygenase |
Most abundant in liver |
| Q9JMA7 |
|
|
Cytochrome P450 |
Monooxygenase |
Liver microsomes |
|
a Annotation obtained from Swiss-Prot.
b No GO term available.
