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Molecular & Cellular Proteomics 6:64-71, 2007.
© 2007 by The American Society for Biochemistry and Molecular Biology, Inc.

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Research

Mass Spectrometric Detection of Tissue Proteins in Plasma^*,S

Hui Zhang^,, Alvin Y. Liu^,¶, Paul Loriaux, Bernd Wollscheid^||, Yong Zhou, Julian D. Watts and Ruedi Aebersold^,||

From the Institute for Systems Biology, Seattle, Washington 98103, ^¶ Department of Urology, University of Washington, Seattle, Washington 98195, and ^|| Institute of Molecular Systems Biology, Swiss Federal Institute of Technology (ETH) Zurich and Faculty of Sciences, University of Zurich, CH-8093 Zurich, Switzerland

It has long been thought that blood plasma could serve as a window into the state of one’s organs in health and disease because tissue-derived proteins represent a significant fraction of the plasma proteome. Although substantial technical progress has been made toward the goal of comprehensively analyzing the blood plasma proteome, the basic assumption that proteins derived from a variety of tissues could indeed be detectable in plasma using current proteomics technologies has not been rigorously tested. Here we provide evidence that such tissue-derived proteins are both present and detectable in plasma via direct mass spectrometric analysis of captured glycopeptides and thus provide a conceptual basis for plasma protein biomarker discovery and analysis.

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