MCP Waters-The Science of What's Possible
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

A more recent version of this article appeared on January 1, 2004.
This Article
Right arrow Full Text (PDF)
Right arrow Supplemental Data
Right arrow All Versions of this Article:
M300072-MCP200v1
3/1/93    most recent
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Glossary
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tien, A.-C.
Right arrow Articles by Huang, C.-Y. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tien, A.-C.
Right arrow Articles by Huang, C.-Y. F.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Submitted on July 23, 2003
Revised on November 5, 2003
Accepted on November 5, 2003

Identification of the substrates and interaction proteins of Aurora kinases from a protein-protein interaction model

An-Chi Tien, Ming-Hong Lin, Li-Jen Su, Yi-Ren Hong, Tai-Shan Cheng, Yuan-Chii G. Lee, Wey-Jinq Lin, Ivan H. Still, and Chi-Ying F. Huang

Molecular and Genomic Medicine, National Health Research Institutes, Taipei, Taiwan 115

Corresponding Author: chiying{at}nhri.org.tw

The increasing use of high throughput and large-scale bioinformatics based studies has generated a massive amount of data stored in a number of different databases. The major need now is to explore this disparate data to find biological relevant interactions and pathways. Thus, in the post-genomic era, there is clearly a need for the development of algorithms that can accurately predict novel protein-protein interaction networks in silico. The evolutionarily conserved Aurora-family kinases have been chosen as a model for the development of a method to identify novel biological networks by a comparison of human and various model organisms. Our search methodology was designed to predict and prioritize molecular targets for Aurora family kinases, so that only the most promising are subjected to empirical testing. Four potential Aurora substrates and/or interacting proteins, TACC3, survivin, Hec1, and hsNuf2, were identified and empirically validated. Together, these results justify the timely implementation of in silico biology in routine wet-lab studies and have also allowed the application of a new approach to the elucidation of protein function in the post-genomic era.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 JCBHome page
K. Kinoshita, T. L. Noetzel, L. Pelletier, K. Mechtler, D. N. Drechsel, A. Schwager, M. Lee, J. W. Raff, and A. A. Hyman
Aurora A phosphorylation of TACC3/maskin is required for centrosome-dependent microtubule assembly in mitosis
J. Cell Biol., September 26, 2005; 170(7): 1047 - 1055.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
C.-T. R. Yu, J.-M. Hsu, Y.-C. G. Lee, A.-P. Tsou, C.-K. Chou, and C.-Y. F. Huang
Phosphorylation and Stabilization of HURP by Aurora-A: Implication of HURP as a Transforming Target of Aurora-A
Mol. Cell. Biol., July 15, 2005; 25(14): 5789 - 5800.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J.-C. Wu, T.-Y. Chen, C.-T. R. Yu, S.-J. Tsai, J.-M. Hsu, M.-J. Tang, C.-K. Chou, W.-J. Lin, C.-J. Yuan, and C.-Y. F. Huang
Identification of V23RalA-Ser194 as a Critical Mediator for Aurora-A-induced Cellular Motility and Transformation by Small Pool Expression Screening
J. Biol. Chem., March 11, 2005; 280(10): 9013 - 9022.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
R. Gassmann, A. Carvalho, A. J. Henzing, S. Ruchaud, D. F. Hudson, R. Honda, E. A. Nigg, D. L. Gerloff, and W. C. Earnshaw
Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle
J. Cell Biol., July 19, 2004; 166(2): 179 - 191.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
 All ASBMB Journals   Journal of Biological Chemistry 
 Journal of Lipid Research   ASBMB Today 
Copyright © 2003 by the American Society for Biochemistry and Molecular Biology.