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A more recent version of this article appeared on May 1, 2003.
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Submitted on April 29, 2003
Revised on May 29, 2003
Accepted on May 29, 2003

Breast cancer: when proteomics challenges biological complexity

Hubert Hondermarck

UPRES-EA 1033, University of Lille 1, Villeneuve d'Ascq 59655

Corresponding Author: hubert.hondermarck{at}univ-lille1.fr

Proteomics is now entering into the field of biomedicine with declared hopes for the identification of new pathological markers and therapeutic targets. Current proteomic tools allow large-scale/high-throughput analyses for the detection, identification, and functional investigation of low abundant proteins. However the major limitation of proteomic investigations remains the complexity of biological structures and physiological processes, rendering the path of exploration of related pathologies paved with various difficulties and pitfalls. The case of breast cancer illustrates the major challenge facing modern proteomics and more generally post-genomics : to tackle the complexity of life.


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