Submitted on August 13, 2003
Revised on November 16, 2003
Accepted on November 16, 2003
Mass spectrometric approaches using electrospray ionization charge states and hydrogen-deuterium exchange for determining protein structures and their conformational changes
Xuguang Yan, Jeffrey Watson, P. Shing Ho, and Max L. Deinzer
Department of Chemistry, Oregon State University, Corvallis, Oregon 97331
Corresponding Author: Max.Deinzer{at}orst.edu
This manuscript is submitted in response to an invitation from Dr. Ralph A. Bradshaw letter 03/15/02)for a review/perspectives paper on hydrogen/deuterium exchange and mass spectrometry analysis in proteins. Three main topics were critically reviewed including electrospray ionization charge states, site specific amide hydrogen exchange, and peptic peptide H/D analysis after deuterium exchange-in for the purpose of determining protein conformations and conformational changes.
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