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A more recent version of this article appeared on October 1, 2006.
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Submitted on May 12, 2006
Accepted on May 30, 2006

Proteomics in clinical trials and practice: present uses and future promise

Nilofer S. Azad, Nabila Rasool, Christina M. Annunziata, Lori Minasian, Gordon Whitely, and Elise C. Kohn

Medical Oncology Branch, National Cancer Institute, Bethesda, MD 20892

Corresponding Author: azadn{at}mail.nih.gov

The proteome consists of all of the protein products that are derived from an individual’s full genetic code. Proteomics bridges the gap between what is encoded in the genome and its translation into proteins. Proteins, rmore than genes, represent the functional output of a cell. Proteomics offers more complexity but potentially more specificity than examining genes alone. The study of proteomics can generally be divided into two categories: 1) the characterization of protein expression and 2) the characterization of protein function. This review details the techniques and possible clinical applications thus far of both expression and functional proteomics.


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