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On the cover, researchers at the Danish Centre for Translational Research in Breast Cancer are applying various experimental paradigms from genomics, proteomics, and functional genomics to the analysis fo biopsies dissected from the same tumor. Data will be shared through a large database supported by the Image Informatics Platform-SIMS (Scimagix), a Web-based system that allows management, mining, and integration of image data generated across experiments and research sites. For details see the article by Celis, pages 369-377.