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On the cover, a network diagram describes the activating interactions (green arrows), inhibitory interactions (red arrows), and transcriptional interactions (blue arrows) shared by the sepsis-induced cytokine α and the growth factor insulin. Red, green, and orange regions indicate apoptotic, survival, and stress pathways, respectively. Gray nodes highlight kinases measured by a high-throughput multiplex kinase activity assay. For details see the article by Janes et al., pages 474-484.