About the Cover
On the cover, the tumor interstitial fluid (TIF) that perfuses breast invasive ductal carcinomas was analyzed using gel-based proteomics, Western immunoblotting, and cytokine-specific antibody arrays. The TIF was found to be composed of more than 1,000 proteins–either secreted, shed by membrane vesicles, or leaked due to cell death–produced by the complex network of cell types that make up the tumor microenvironment. For details, see the article by Celis et al., pages 327—344.
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Copyright © 2008 by the American Society for Biochemistry and Molecular Biology.
