About the Cover
On the cover, the ionic interactions of the transferrin C-lobe with one monomer of the transferrin receptor dimer are illustrated as guiding the complex formation. Multiple basic residues on the receptor (middle, gray) helical domain and multiple acidic residues on transferrin C-lobe (bottom left, brown) are involved in the interface. The three green beams symbolize the ion pair interactions between oppositely charged binding partners. The transferrin N-lobe (bottom right, sky blue) is indicated as in the process of binding to the bottom of one monomer of the receptor helical domain dimer. At the top is another nearby transferrin molecule that will bind receptor to form the overall 2:2 complex. For details, see the article by Xu et al., pages 1959–1967.
[Table of Contents]
Copyright © 2008 by the American Society for Biochemistry and Molecular Biology.
