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On the cover, several representatives of the human cell pocketome, a collection of thousands of small-molecule binding envelopes in a cell proteome. The binding envelopes, shown in yellow, were predicted from three-dimensional models of proteins without using any knowledge of bound ligands (shown in stick models). The envelopes can be clustered into categories according to their size, shape, and psysiocochemical properties. For details, see the article by An et al., pages 752–761.
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