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On the cover, CAX-PAGE/RPLC-MSMS proteomics platform for discovery of protein biomarkers of traumatic brain injury. Applied to naïve and injured tissue from a controlled cortical impact rat model, proteins are resolved by multidimensional separations and quantified by densitometry. Peptide identification and quantitation are then performed and correlated with protein data. A total of 59 differential proteins were identified. Validation of subsequent protein hits was performed and correlated to biological function. For details, see the article by Kobeissy et al., pages 1887-1898.

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