About the Cover
On the cover, inactive Akt displays a folded structure in cytosol. Upon membrane interaction the pleckstrin homology and regulatory domains move away from the kinase domain exposing Thr308 and Ser473 for phosphorylation. When activated by phosphorylation, the pleckstrin homology domain closes, possibly enabling the separation of Akt from membrane. The regulatory domain remains open allowing substrate entry. Upon substrate binding a closed conformation is reestablished. For details, see the article by Huang and Kim, pages 1045–1053.
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Copyright © 2007 by the American Society for Biochemistry and Molecular Biology.
