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On the cover, 2D-DIGE is used to identify proteins involved in cytokine-induced β-cell death in a model for type 1 diabetes. Network analysis, making use of a brand new bioinformatics program, reveals that many of these proteins act in a proteome-interactome. These new findings widen our view on the understanding of the pathways involved in β-cell death. For details, see the article by D'Hertog et al., pages 2180–2199.
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