Table I

Matrix mutation

The procedure of matrix mutation improved the leave-one-out validation significantly, whereas the self-consistency performance was only moderately influenced. Here we fixed Sp at 90% to improve Sn by matrix mutation. PKC, protein kinase C; MAPKAPK, MAPK-activated protein kinase.

PK clusterBefore MMaAfter MMb
SelfcLOOdSelfLOO
%%
AGC/PKA87.582.291.189.6
AGC/PKC/α90.049.278.368.3
Atypical/PIKK90.162.696.786.8
CaMK/CaMKII/CaMKII-α100.069.0100.093.1
AGC/AKT96.486.998.892.9
AGC/GRK90.552.398.861.9
AGC/PKC72.764.179.275.0
AGC/RSK98.276.8100.083.9
CaMK/CaMKII97.767.496.581.4
CaMK/MAPKAPK100.043.8100.062.5
CMGC/CDK88.583.892.188.1
Other/CK277.674.380.278.8
  • a Before matrix mutation.

  • b After matrix mutation.

  • c Self, self-consistency Sn.

  • d LOO, the Sn of leave-one-out validation.