Table IV Performance comparison of Musite with existing kinase-specific prediction tools

Sensitivities (Sn) at different specificities (Sp) were compared. Different specificity levels were taken as similar as possible (in each column) among different tools. The best performed result in each specificity level (column) for each kinase or kinase family is highlighted in bold. LOO and Self stand for “leave-one-out cross-validation test” and “self-consistency test,” respectively.

PKA
    ScanSite 1.0
        Sp (%)a99.8399.0897.03
        Sn (%)16.6741.8861.54
    GPS 2.1
        Sp (%)99.9999.9099.8099.5099.0098.0097.0095.0090.00
        Sn (%)0.858.1219.6632.9149.5758.9767.5272.6583.76
    NetPhosK 1.0
        Sp (%)99.9999.9099.7999.4699.0297.9897.0695.1689.86
        Sn (%)1.598.4713.7623.8128.0438.6248.6856.0872.49
    pkaPS
        Sp (%)99.9999.9099.8099.5099.0098.0097.0095.0590.06
        Sn (%)1.718.1215.3831.6242.7358.1266.6773.9385.04
    Musite 1.0LOO
        Sp (%)99.9999.9099.8099.5099.0098.0297.1095.0890.03
        Sn (%)0.436.8416.6731.6244.8757.2663.6872.7981.62
    Musite 1.0Self
        Sp (%)99.9999.9099.8099.5099.0098.0097.0095.0090.00
        Sn (%)1.718.9718.8034.6247.0158.5569.2374.3685.47
CK2
    ScanSite 1.0
        Sp (%)99.8799.1496.8
        Sn (%)14.2236.4459.6
    GPS 2.1
        Sp (%)99.9999.9099.8099.5099.0098.0097.0095.0090.00
        Sn (%)4.8713.7220.3536.7349.5661.9568.5874.3482.74
    NetPhosK 1.0
        Sp (%)99.9999.8999.7199.4798.9197.8097.0695.0289.83
        Sn (%)3.6613.6120.4229.3237.7051.3155.5062.3074.35
    Musite 1.0LOO
        Sp (%)99.9999.9099.8099.4999.0098.0497.0295.0489.99
        Sn (%)5.5814.6022.5734.5149.1260.6266.8172.1281.42
    Musite 1.0Self
        Sp (%)99.9999.9099.8099.5099.0098.0097.0095.0090.00
        Sn (%)6.1915.0423.4537.6148.6760.6268.5875.6683.63
MAPK
    GPS 2.1
        Sp (%)99.9999.9099.8099.5099.0098.0097.0095.0090.00
        Sn (%)0.002.2611.7618.1024.8940.2752.0471.0481.00
    Musite 1.0LOO
        Sp (%)99.9999.9099.8099.5099.0098.0096.9995.0290.93
        Sn (%)0.902.265.4318.1027.1537.1044.8062.9081.90
    Musite 1.0Self
        Sp (%)99.9999.9099.8099.5099.0098.0097.0095.0090.00
        Sn (%)0.914.524.9815.3827.1538.4647.0663.3581.90
  • a —, the prediction result at this specificity level was not available for this tool.