Table I Association of signaling endosome components with human pathologies. Disease enrichment analysis was performed with Metacore using a hypergeometric test. The ratios between endosomal protein-coding genes and independent genes indicate the possible association of any given gene with neurological diseases. Selected genesets are listed in order of their statistical significance after Benjamini-Hochberg correction. p values < 0.05 are significant. Neurological diseases associated with axonal transport deficits are highlighted in bold. Neurological infections are marked with asterisks. Adj.p.value: adjusted p value
Disease nameadj.p.valRatio
Central nervous system Diseases1.89E-47459/3069
Brain diseases6.73E-46435/2880
Schizophrenia6.25E-43203/914
Schizophrenia and disorders with psychotic features9.56E-43203/918
Neurodegenerative diseases2.74E-39336/2104
Mental disorders3.50E-39281/1614
Nervous system diseases3.50E-39665/5522
Psychiatry and psychology8.79E-36307/1919
Dementia9.48E-32255/1536
Tauopathies6.13E-29206/1166
Alzheimer's disease2.04E-27201/1153
Virus diseases*1.68E-17215/1531
TDP-43 proteinopathies2.55E-1754/180
Amyotrophic lateral sclerosis9.00E-1753/179
Heredodegenerative disorders, nervous system1.19E-16163/1064
Glioblastoma7.15E-16311/2579
Astrocytoma9.92E-16315/2628
Epilepsy1.09E-1590/455
Basal ganglia diseases5.70E-15129/799
Movement disorders3.01E-14135/871
Neuromuscular diseases1.31E-13176/1278
Spinal cord diseases2.14E-1372/352
Neurologic manifestations2.38E-13204/1566
Motor neuron disease2.76E-1359/257
Tay-Sachs disease8.24E-1312/12
Dyskinesias8.98E-13117/745
Brain diseases, metabolic1.71E-1262/290
Bacterial infections and mycoses*1.76E-12175/1307
Glioma2.44E-12534/5313
RNA virus infections*4.27E-12148/1055
Brain diseases, metabolic, inborn9.98E-1259/279
Neoplasms, neuroepithelial1.00E-11554/5596
Infection*7.58E-11157/1185
Down syndrome1.94E-1042/173
Huntington's disease4.97E-0975/461
Lysosomal storage diseases, Nervous system5.14E-0923/67
Parkinsonian disorders2.45E-0558/405
Frontotemporal lobar Degeneration2.24E-0418/80
Frontotemporal dementia2.24E-0418/80