Table III

Sequence similarity versus Binders. The “Binders” column indicates the number of peptides selected from the microarray experiments and the “Aligners” are the number of peptides that had sequence similarity with the known epitope as described in the Methods section. The number of peptides in common between the “Binders” and “Aligners” lists is in the “Both” column. “Expected” column lists the number of peptides expected to be in common if lists were drawn at random from the peptide library. “Ratio” is the ratio of “Both” to “Expected.” The percentage of the “Binders” list that is in “Both” is in the last column. The “p Value” describes the probability that the “Binder” and “Aligner” list overlap as much as in the “Both” list by chance based on the Fisher's Exact test

BindersAlignerBothExpectedRatio% Of Binders alignp Value
mAb135018165.881.021.70%0.551
mAb23913792113.751.535.40%0.062
mAb3379188366.615.459.50%<0.001
mAb43549623.150.630.60%0.334
mAb5369365612.50.481.60%0.016
pAb12587222617.281.510.10%0.053
pAb22587552618.071.4410.10%0.068
pAb32637101817.321.046.80%0.493
pAb42747422218.861.178.00%0.424
pAb52676992117.311.217.90%0.301
Average316.3483.718.413.071.556.20%0.232