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Molecular & Cellular Proteomics

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Cross-species comparison of proteome turnover kinetics

Kyle Swovick, Kevin A Welle, Jennifer Hryhorenko, Andrei Seluanov, Vera Gorbunova and Sina Ghaemmaghami  Correspondence email
Molecular & Cellular Proteomics January 10, 2018, mcp.RA117.000574; https://doi.org/10.1074/mcp.RA117.000574
Kyle Swovick
University of Rochester, United States of America
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Kevin A Welle
University of Rochester
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Jennifer Hryhorenko
University of Rochester
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Andrei Seluanov
University of Rochester, United States of America
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Vera Gorbunova
University of Rochester, United States of America
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Sina Ghaemmaghami
Institute for Neurodegenerative Diseases, University of Rochester, United States of America
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  • For correspondence: sghaemma@bio.rochester.edu
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Abstract

The constitutive process of protein turnover plays a key role in maintaining cellular homeostasis. Recent technological advances in mass spectrometry have enabled the measurement of protein turnover kinetics across the proteome. However, it is not known if turnover kinetics of individual proteins are highly conserved or if they have evolved to meet the physiological demands of individual species. Here, we conducted systematic analyses of proteome turnover kinetics in primary dermal fibroblasts isolated from eight different rodent species. Our results highlighted two trends in the variability of proteome turnover kinetics across species. First, we observed a decrease in cross-species correlation of protein degradation rates as a function of evolutionary distance. Second, we observed a negative correlation between global protein turnover rates and maximum lifespan of the species. We propose that by reducing the energetic demands of continuous protein turnover, long-lived species may have evolved to lessen the generation of reactive oxygen species and the corresponding oxidative damage over their extended lifespans.

  • proteostasis
  • Aging
  • Protein Degradation*
  • Protein Turnover*
  • Quantification
  • SILAC

Footnotes

  • Author contributions: K.S. and S.G. designed research; K.S., K.A.W., and J.H. performed research; K.S. and S.G. analyzed data; K.S. and S.G. wrote the paper; A.S. and V.G. contributed new reagents/analytic tools.

  • Received December 21, 2017.
  • Accepted January 10, 2018.
  • Published under license by The American Society for Biochemistry and Molecular Biology, Inc.
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Cross-species comparison of proteome turnover kinetics
Kyle Swovick, Kevin A Welle, Jennifer Hryhorenko, Andrei Seluanov, Vera Gorbunova, Sina Ghaemmaghami
Molecular & Cellular Proteomics January 10, 2018, mcp.RA117.000574; DOI: 10.1074/mcp.RA117.000574

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Cross-species comparison of proteome turnover kinetics
Kyle Swovick, Kevin A Welle, Jennifer Hryhorenko, Andrei Seluanov, Vera Gorbunova, Sina Ghaemmaghami
Molecular & Cellular Proteomics January 10, 2018, mcp.RA117.000574; DOI: 10.1074/mcp.RA117.000574
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