Skip to main content
Molecular & Cellular Proteomics

Main menu

  • Home
  • Articles
    • Current Issue
    • Papers in Press
    • Reviews and Minireviews
    • Special Issues
    • Editorials
    • Archive
    • Letters to the Editor (eLetters)
  • Info for
    • Authors
      • Editorial Policies
      • How to Submit
      • Manuscript Contents & Organization
      • Data Reporting Requirements
      • Publication Charges
    • Reviewers
    • Librarians
    • Advertisers
    • Subscribers
  • Guidelines
    • Proteomic Identification
      • Checklist (PDF)
      • Instructions for Annotated Spectra
      • Tutorial (PDF)
    • Clinical Proteomics
      • Checklist (PDF)
    • Glycomic Identification
      • Checklist (PDF)
    • Targeted Proteomics
      • Checklist (PDF)
    • Data-Independent Acquisition
      • Checklist (PDF)
    • Frequently Asked Questions
  • About
    • Mission Statement and Scope
    • Editorial Policies
    • Editorial Board
    • MCP Lectureships
    • Permissions and Licensing
    • Partners
    • Alerts
    • Contact Us

Submit

  • Submit
  • Publications
    • ASBMB
    • Molecular & Cellular Proteomics
    • Journal of Biological Chemistry
    • Journal of Lipid Research

User menu

  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
  • Publications
    • ASBMB
    • Molecular & Cellular Proteomics
    • Journal of Biological Chemistry
    • Journal of Lipid Research
  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart
Molecular & Cellular Proteomics

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Papers in Press
    • Reviews and Minireviews
    • Special Issues
    • Editorials
    • Archive
    • Letters to the Editor (eLetters)
  • Info for
    • Authors
      • Editorial Policies
      • How to Submit
      • Manuscript Contents & Organization
      • Data Reporting Requirements
      • Publication Charges
    • Reviewers
    • Librarians
    • Advertisers
    • Subscribers
  • Guidelines
    • Proteomic Identification
      • Checklist (PDF)
      • Instructions for Annotated Spectra
      • Tutorial (PDF)
    • Clinical Proteomics
      • Checklist (PDF)
    • Glycomic Identification
      • Checklist (PDF)
    • Targeted Proteomics
      • Checklist (PDF)
    • Data-Independent Acquisition
      • Checklist (PDF)
    • Frequently Asked Questions
  • About
    • Mission Statement and Scope
    • Editorial Policies
    • Editorial Board
    • MCP Lectureships
    • Permissions and Licensing
    • Partners
    • Alerts
    • Contact Us
  • Submit
Research

Protein palmitoylation plays an important role in Trichomonas vaginalis adherence

Yesica R Nievas, Ajay A Vashisht, Maria M Corvi, Sebastian Metz, Patricia J Johnson, James A Wohlschlegel and Natalia de Miguel  Correspondence email
Molecular & Cellular Proteomics February 14, 2018, mcp.RA117.000018; https://doi.org/10.1074/mcp.RA117.000018
Yesica R Nievas
IIB-INTECH, CONICET-UNSAM, Argentina
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ajay A Vashisht
Genomics Institute of the Novartis Research Foundation, United States of America
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Maria M Corvi
IIB-INTECH, CONICET-UNSAM, Argentina
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sebastian Metz
IIB-INTECH, CONICET-UNSAM, Argentina
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Patricia J Johnson
UCLA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
James A Wohlschlegel
University of California, Los Angeles, United States of America
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Natalia de Miguel
Laboratorio de Parásitos Anaerobios, IIB-INTECH, CONICET-UNSAM, Argentina
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: ndemiguel@intech.gov.ar
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Abstract

The flagellated protozoan parasite Trichomonas vaginalis is the etiologic agent of trichomoniasis, the most common non-viral sexually transmitted infection worldwide. As an obligate extracellular pathogen, adherence to epithelial cells is critical for parasite survival within the human host and a better understanding of this process is a prerequisite for the development of therapies to combat infection. In this sense, recent work has shown S-acylation as a key modification that regulates pathogenesis in different protozoan parasites. However, there are no reports indicating whether this post-translational modification is a mechanism operating in T. vaginalis. In order to study the extent and function of S-acylation in T. vaginalis biology, we undertook a proteomic study to profile the full scope of S-acylated proteins in this parasite and reported the identification of 363 proteins involved in a variety of biological processes such as protein transport, pathogenesis related and signaling, among others. Importantly, treatment of parasites with the palmitoylation inhibitor 2-bromopalmitate causes a significant decrease in parasite: parasite aggregation as well as adherence to host cells suggesting that palmitoylation could be modifying proteins that are key regulators of Trichomonas vaginalis pathogenesis.

  • Parasite
  • Palmitoylation
  • Adherence
  • Cell adhesion*
  • Host-Pathogen Interaction
  • Infectious disease
  • Microbiology
  • Parasite
  • Pathogens
  • Post-translational modifications*
  • Protein Modification*

Footnotes

  • Author contributions: Y.R.N., M.M.C., and N.d.M. designed research; Y.R.N., A.A.V., and J.A.W. performed research; Y.R.N., A.A.V., S.M., P.J.J., J.A.W., and N.d.M. analyzed data; Y.R.N., J.A.W., and N.d.M. wrote the paper; M.M.C., S.M., P.J.J., and N.d.M. contributed new reagents/analytic tools.

  • Received May 31, 2017.
  • Revision received January 3, 2018.
  • Accepted February 14, 2018.
  • Published under license by The American Society for Biochemistry and Molecular Biology, Inc.
PreviousNext
Back to top
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on Molecular & Cellular Proteomics.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Protein palmitoylation plays an important role in Trichomonas vaginalis adherence
(Your Name) has sent you a message from Molecular & Cellular Proteomics
(Your Name) thought you would like to see the Molecular & Cellular Proteomics web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Protein palmitoylation plays an important role in Trichomonas vaginalis adherence
Yesica R Nievas, Ajay A Vashisht, Maria M Corvi, Sebastian Metz, Patricia J Johnson, James A Wohlschlegel, Natalia de Miguel
Molecular & Cellular Proteomics February 14, 2018, mcp.RA117.000018; DOI: 10.1074/mcp.RA117.000018

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Request Permissions

Share
Protein palmitoylation plays an important role in Trichomonas vaginalis adherence
Yesica R Nievas, Ajay A Vashisht, Maria M Corvi, Sebastian Metz, Patricia J Johnson, James A Wohlschlegel, Natalia de Miguel
Molecular & Cellular Proteomics February 14, 2018, mcp.RA117.000018; DOI: 10.1074/mcp.RA117.000018
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Figures & Data
  • eLetters
  • Info & Metrics
  • PDF

  • Follow MCP on Twitter
  • RSS feeds
  • Email

Articles

  • Current Issue
  • Papers in Press
  • Archive

For Authors

  • Submit a Manuscript
  • Info for Authors

Guidelines

  • Proteomic Identification
  • Clinical Proteomics
  • Glycomic Identification
  • Targeted Proteomics
  • Frequently Asked Questions

About MCP

  • About the Journal
  • Permissions and Licensing
  • Advertisers
  • Subscribers

ASBMB Publications

  • Molecular & Cellular Proteomics
  • Journal of Biological Chemistry
  • Journal of Lipid Research
  • ASBMB Today

© 2019 American Society for Biochemistry and Molecular Biology | Privacy Policy

MCP Print ISSN 1535-9476 Online ISSN 1535-9484

Powered by HighWire