Proteomics in Infectious Disease



  • This special collection of 20 articles, coordinated by Ileana Cristea at Princeton University, highlights and celebrates the contribution of proteomics to fundamental discoveries in infectious disease research. These versatile proteomic technologies have led to the discovery of mechanisms that underlie pathogen replication or host defense, as well as the characterization of pathogen composition and features that contribute to its virulence. This issue tries to capture some of the diverse infectious disease studies that have benefited from the integration of proteomics methods.

    Click one of the links below to download a printable poster featuring the cover art for this Special Issue:

    PDF, 11 x 17 inches, 3.5 MB

    PDF, 8.5 x 11 inches, 3.5 MB

    On the cover: Oil on canvas art illustrating the process of viral infection triggering alterations in the infected cell. A viral particle (pink) infects the cell, depositing its genomic material and initiating a cascade of viral gene expression to promote viral replication. The arms emanating from the viral particle to “control” the host proteome are an abstract representation of the result of viral infection. Represented by the top right arm, viral proteins (pink) are produced to regulate the immune defense, host metabolism, and the assembly of viral particles. The arm at the bottom represents regulation of host proteins (red) through alteration in protein abundances, localization, or post-translational modifications. This artwork was executed by Carla Vendrell, graphic designer and illustrator, with input from Pierre M. Jean Beltran, graduate student from the Cristea laboratory at Princeton University.