Special Issues

Special Issue: Reproductive Proteomics

March 2019 -- This special collection of 13 articles, coordinated by Associate Editor Timothy Karr at Arizona State University, highlights recent discoveries in sperm and egg biology. The contributions in this issue of Molecular & Cellular Proteomics, are intended to showcase the power of proteomics to discover new pathways and processes, and to tackle existing problems and areas of sexual reproduction previously refractory to conventional approaches.

Special Issue: Proteomics in Infectious Disease

April 2017--This special collection of 20 articles, coordinated by Ileana Cristea at Princeton University, highlights and celebrates the contribution of proteomics to fundamental discoveries in infectious disease research. These versatile proteomic technologies have led to the discovery of mechanisms that underlie pathogen replication or host defense, as well as the characterization of pathogen composition and features that contribute to its virulence. This issue tries to capture some of the diverse infectious disease studies that have benefited from the integration of proteomics methods.

Click here for a printable poster of this Special Issue cover

Special Issue: Chromatin Biology and Epigenetics

March 2016--This edition of MCP includes a compilation of 16 articles coordinated by Ben Garcia of University of Pennsylvania School of Medicine, Mike Washburn of the Stowers Institute for Medical Research, and Yingming Zhao of University of Chicago. This group of articles details new advances in instrumentation and methods allowing for better measurement of chromatin targets, as well as the continuing study of epigenetics, heritable changes in gene expression not due to changes in DNA sequence that alter the way gene sequences are read, which can lead to disease.

Special Issue: Neuroproteomics

February 2016--This edition of MCP features a collection of 15 articles coordinated by Jeffery Twiss of University of South Carolina and Mike Fainzilber of Weizmann Institute of Science. These articles focus on application of proteomics to current problems in neuroscience, in the hope that the neuroscience community will embrace proteomics approaches to help answer their complex questions. Successful methodologies are presented as examples of how these technologies can be used to provide new insights and knowledge in this ever expanding field of medicine.

Special Issue: Eleventh International Symposium on Mass Spectrometry in the Health and Life Sciences

September 2015--This autumn issue of MCP includes a collection of 11 articles by speakers at The 11th International Symposium on Mass Spectrometry and Proteomics. The meeting, which took place in San Francisco in August 2014, is regarded as one of the preeminent forums for the discussion of mass spectrometry instrumentation, techniques, and analytical tools and their impact on the life sciences, and the goal of this meeting is to integrate the perspectives of mass spectrometry with the needs of the biomedical and clinical sciences.

Special Issue: Changing the View of Complex Systems: The National Technology Centers for Networks and Pathways

November 2014--This issue of MCP includes the special series “Changing the View of Complex Systems: The National Technology Centers for Networks and Pathways,” coordinated by Jon Aitchison of Seattle Biomedical Research Institute. The 10-article series focuses on research supported by the National Institutes of Health Common Fund. The program’s research focused on developing and using proteomics to better understand the spatial and temporal dynamics of protein interactions.

Special Issue: Proteomics in Europe

August 2014--This special summer issue features a substantial collection of articles describing recent research findings supported by the European Union-funded proteomics consortium known as PRIME-XS (Proteomics Research Infrastructure Maximising knowledge Exchange and access). The consortium’s 12 partner institutions offer specialized instrumentation, expertise and training that have assisted in yielding more than 100 publications since its first call for proposals in July 2011.

Special Issue: Post-translational Modifications

December 2013--This special issue on post-translational modifications of proteins grew out of the bi-annual Special Symposium “Post Translational Modifications: Detection and Physiological Roles,” held at Lake Tahoe in October of 2012. Articles in this issue illustrate ongoing work in the field of PTMs that builds upon the advances in proteomics made during the past decades. To visually capture the complex intricacies of the molecular biology involved in post-translational modifications, certified medical illustrator Jennifer Fairman designed several of the figures, as well as its cover art.

Special Issue: Glycomics

April 2013--In this special issue, we highlight a wide variety of glycomic approaches, through mini-reviews and research articles, that not only advance our understanding of the structural complexity and functional diversity of glycans and glycoconjugates, but also build upon the existing tools and technologies developed by the proteomics community.

Special Issue: Proteomics of Protein Degradation and Ubiquitin Pathways

December 2012--This special issue contains talks given at the January 2012 Conference on Proteomics of Protein Degradation and Ubiquitin Pathways (PPDUP), held in San Diego. To gain insights into both the current state-of-the-art proteomic methods to investigate protein turnover, and how protein degradation function is altered within a range of human disorders a variety of speakers revealed the many connections between altered protein degradation function and human disease. Many of the sessions were framed by a consistent focus aimed at the discovery and development of novel therapeutics targeting protein degradation pathway components to treat various human maladies ranging from cancer to heart disease.

Special Issue: Mass Spectrometry

May 2012--The articles contained in this special issue are a representative sampling of presentations given at The 10th International Symposium on Mass Spectrometry in the Health and Life Sciences: Molecular and Cellular Proteomics was held in San Francisco in August 2011. These presentations illustrate both the technical advances and the practical applications of mass spectrometry to proteomic analyses in the past 2 years.

Special Issue: Prospects in Space and Time

March 2012--This special issue presents 16 research papers reporting major recent progress by the Proteomics Specification in Time and Space (PROSPECTS) groups, including improvements to the resolution and sensitivity of the Orbitrap family of mass spectrometers, systematic detection of proteins using highly characterized antibody collections, and new methods for absolute as well as relative quantification of protein levels. The PROSPECTS Network is a unique EU-funded project that brings together leading European research groups, spanning from instrumentation to biomedicine, in a collaborative five year initiative to develop new methods and applications for the functional analysis of cellular proteins. Manuscripts in this issue exemplify approaches for performing quantitative measurements of cell proteomes and for studying their dynamic responses to perturbation, both during normal cellular responses and in disease mechanisms.

Special Issue: Proteomics of Protein Degradation and Ubiquitin Pathways

May 2011--This special issue is dedicated to highlight outstanding scientific advances reported at the 2010 Proteomics of Protein Degradation and Ubiquitin Pathways (PPDUP) meeting in Vancouver, British Columbia, Canada. This conference was jointly sponsored by the International Forum of Proteomics and Proteomics of Protein Degradation and Ubiquitin Pathways, and it was the first of a series of conferences on the related topic. The major goal of this series of conferences is to promote the elucidation of protein degradation pathways and the understanding of downstream physiologic consequences using cutting-edge proteomic tools. The main biological questions revolve around how cells manage their protein quality of life and how proteins are processed when they reach the end of their road. Scientific content covered by this international conference spanned a wide range of topics all converging on protein misfolding, protein quality control, and all relevant protein degradation pathways.

Special Issue: Technology Development

February 2011--This issue contains special contributions from 10 authors who spoke at the HUPO 2009 and focuses on newly emerging "state of the art" techniques in proteomics. These articles cover a wide range of topics from novel methods for proteolytic digestion to protein cross-linking and MALDI imaging. These reflect some of the areas without which the key programs for the Human Proteomic Project cannot succeed. These topics include sample preparation; methods for membrane protein analysis; techniques for absolute quantification of proteins, especially MRM1 analysis, which will be essential for biomarker verification and validation/qualification (the next step in the development of real clinical applications of protein biomarkers); phosphoproteomics methods; molecular imaging; and new techniques for structural proteomics, including cross-linking and top-down methods, which can provide the basis for "intelligent drug design," and—fundamental to all of these other techniques—advances in instrument development.

Special Issue: 9th International Symposium On Mass Spectrometry in the Health & Life Sciences

May 2010--This issue contains 21 articles from the 9th International Symposium on Mass Spectrometry in the Health and Life Sciences held Aug. 23- 27 in San Francisco, Calif. The emphasis of the articles is on the advances in mass spectrometry and supporting technologies.

Mini Symposium on the Relative Merits of Orthogonal Energy Deposition Modes for Promotion of Fragmentation

August 2009--Sessions covered in this special issue include: Global Analysis of Small Molecule Interactions with Proteins, Quantitative Analysis of Proteome Localization and Dynamics, Characterization and Quantification of Phosphosites in the Proteome of Human Primary T-Lymphocytes and more.

Clinical Proteomics

October 2008--Content categories in this special issue include: Biomarkers of Disease and Conditions, Pathway Proteomics and Post-Translational Modifications, and Methodologies.

Special Issue: 8th International Symposium On Mass Spectrometry In The Life Sciences

April 2008--This special issue of Molecular & Cellular Proteomics will highlight some of the research presented at the 8th International Symposium on Mass Spectrometry in the Health and Life Sciences, held this past August in San Francisco. This Symposium described how recent advances in mass spectrometry have expanded our current knowledge about the vast protein networks inside cells and how they are regulated.

Meeting Proceedings: 8th International Symposium on Mass Spectrometry in the Health and Life Sciences (2007)

Read abstract and program guides from the Eighth International Symposium on Mass Spectrometry in the Health and Life Sciences:August 18-23, 2007, San Francisco.

Meeting Proceedings: HUPO 5th Annual World Congress (2006)

October 2006--Read abstracts from HUPO 5th Annual World Congress, October 28-November 1, 2006, Long Beach, CA.

Meeting Proceedings: 7th International Symposium on Mass Spectrometry in the Health and Life Sciences: Molecular & Cellular Proteomics (2005)

August 2005--Read abstract and program guides from the Seventh International Symposium on Mass Spectrometry in the Health and Life Sciences: Molecular & Cellular Proteomics, August 21-25, 2005, San Francisco

Revised Draft Guidelines for Proteomic Data Publication (July 2005)

Meeting Proceedings: HUPO 4th Annual World Congress (2005)

August 2005--Read abstracts and programs from HUPO 4th Annual World Congress, August 29-September 1, 2005, Munich

Meeting Proceedings: HUPO 3rd Annual World Congress (2004)

October 2004--Read abstracts and programs from HUPO 3rd Annual World Congress, October 25-27, Beijing

Meeting Proceedings: 6th International Symposium on Mass Spectrometry in the Health & Life Sciences (2003)

July 2003--Read the program and abstract from the Sixth International Symposium on Mass Spectrometry in the Health & Life Sciences: Molecular & Cellular Proteomics, August 24 - 28, 2003, San Francisco