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- EditorialOpen Access
Initial Guidelines for Manuscripts Employing Data-independent Acquisition Mass Spectrometry for Proteomic Analysis
Molecular & Cellular ProteomicsVol. 18Issue 1p1–2Published online: January 1, 2019- Robert J. Chalkley
- Michael J. MacCoss
- Jacob D. Jaffe
- Hannes L. Röst
Cited in Scopus: 6Proteomic research began largely as an approach for characterizing sample compositions, but most contemporary studies involve a quantitative aspect. Quantification enables comparing sample classes (e.g. healthy versus disease) to uncover markers of dysregulation, or comparing protein pull-down experiments to mock pull-downs to determine specific interaction partners. For small-scale comparisons, isotopic labeling, whether introduced metabolically or chemically, is very effective and allows comparison of multiple samples mixed together.
