Table I

Demographics and clinical data

eGFR, estimated glomerular filtration rate; AI, augmentation index; C1, large artery elasticity index; C2, small artery elasticity index; BMI, body mass index. p values are given for the comparison between CAD at base line and CAD at follow-up. Significant differences between controls and CAD at base line are indicated. Values in parentheses are interquartile range. N/A, not applicable.

Controls (n = 32)CAD, base line (n = 77)CAD, follow-up (n = 82)p
Sex, male/female21/956/2159/230.91
Age (yr)54 ± 1361 ± 11 †62 ± 11N/A
BMI (kg/m2)25.3 ± 3.126.2 ± 4.826.5 ± 4.60.38
Smokers, active/stopped/none3/9/2014/38/25a13/42/270.93
Diabetic, n0670.84
Statin therapy, n075b770.93
Systolic blood pressure (mm Hg)123 ± 12132 ± 20c133 ± 190.42
Diastolic blood pressure (mm Hg)76 ± 776 ± 974 ± 90.15
Total cholesterol (mmol/liter)5.4 ± 0.93.9 ± 0.8b3.8 ± 0.80.24
LDL cholesterol (mmol/liter)3.2 ± 0.71.9 ± 0.7b1.8 ± 0.80.13
HDL cholesterol (mmol/liter)1.5 ± 0.41.2 ± 0.3c1.3 ± 0.30.12
Triglycerides (mmol/liter)1.3 (1.0;2.7)1.5 (1.8; 2.2)1.4 (1.1; 2.1)0.48
C-reactive protein (mg/liter)1.3 (0.3;2.4)2.6 (1.0; 6.3)c1.2 (0.6; 2.2)<0.001
Creatinine (μmol/liter)90 ± 991 ± 2198 ± 230.03
eGFR (ml/min/1.73m2)75 ± 1075 ± 969 ± 14<0.001
AI (%)26.4 ± 11.732.1 ± 10.4a30.5 ± 9.40.18
C1 (ml/mm Hg × 10)14.0 ± 3.911.8 ± 4.3c13.3 ± 4.30.01
C2 (ml/mm Hg × 100)5.7 ± 3.93.8 ± 2.8c3.6 ± 1.60.50
  • a p < 0.05.

  • b p < 0.001.

  • c p < 0.01.