Table II

Proteins whose expression is altered by the expression of four or more oncogenes

Proteins shown are those where a confident assessment of a common decrease or increase in four or more of the six oncogenes was found. To be included the data must contain more than two peptides and have a -fold change (control versus oncogene) <0.8 or >1.2 with a p value of less than 0.05. The significant changes are shown in bold; the underlined values represent “changes” where the confidence levels were not met.

Accession numberIdentity-Fold change (oncogene compared with control)Number of oncogenes in which change were seen
BCR/ABLTEL/PDGFRβNPM/ALKKIT D816VFLT3ITDFIP1/PDGFRα
trm|Q9R126 Eosinophil-associated ribonuclease 7 0.12 0.38 0.06 0.04 0.17 0.32 6
spt|P20152 Vimentin 1.42 1.63 1.90 1.20 1.43 1.135
spt|Q9EQU5 SET protein (phosphatase 2A inhibitor I2PP2A) 0.74 0.68 0.77 0.96 0.80 0.85 5
trm|Q99LB4 Capping protein (CAPG) 0.51 0.91 0.74 0.51 0.67 0.61 5
trm|Q69Z71 Scinderin 0.26 1.48 0.60 0.39 0.41 0.25 5
spt|P25444 40 S ribosomal protein S2 (S4) 1.52 1.001.02 1.21 1.24 1.29 4
spt|P62843 40 S ribosomal protein S15 (RIG protein) 1.36 0.970.98 1.21 1.18 1.27 4
spt|P47968 Ribose-5-phosphate isomerase 0.56 1.07 0.71 0.68 0.58 0.934
trm|Q69ZN0 Guanine deaminase 0.46 0.79 1.27 0.54 0.55 1.31 4
spt|Q61878 Eosinophil granule major basic protein precursor 0.15 0.47 0.47 0.21 0.32 0.23 4
spt|O35381 Acidic nuclear phosphoprotein pp32 0.75 0.95 0.61 0.88 0.79 0.75 4
cra|mCP22728.2 Ferritin light chain 1 0.48 0.83 0.39 0.44 0.44 0.53 4
trm|Q8CJ71 Heterogeneous nuclear ribonucleoprotein 0.73 0.97 0.79 0.70 0.80 0.904
trm|Q9D154 Serine protease inhibitor EIA 0.34 1.34 0.65 0.31 0.71 2.03 4