Table III

Highly disordered cytosolic phosphoproteins

39 phosphoproteins are predicted to be over 70% disordered as assessed by PONDR analysis. 45% of these highly disordered proteins have no known function, whereas 26% are involved in splicing/RNA binding. This list contains three highly disordered proteins (Atrophin-1, Ataxin-1, and Ataxin-2 in bold) that contain trinucleotide repeats that when expanded cause spinocerebellar ataxias.

Functional classGene nameProtein nameLongest disordered region (residues)Disorder
Splicing/RNA binding Srrm2 Serine/arginine repetitive matrix protein 283795.89
DNA binding Nucks1 Nuclear ubiquitous casein and cyclin-dependent kinase substrate18493.59
Signaling Marcks Myristoylated alanine-rich protein kinase C substrate15292.53
Unknown Mtap7d1 Microtubule-associated protein 7 domain-containing 147991.13
Unknown MGC42367 MGC4236738988.63
Unknown8030462N17Rik8030462N17Rik proteina14586.72
Splicing/RNA binding Acin1 Apoptotic chromatin condensation inducer in the nucleus39985.72
Splicing/RNA binding1500011J06Rikpre-mRNA splicing factor SRP5516185.71
Splicing/RNA binding Srrm1 Serine/arginine repetitive matrix protein 168785.41
Unknown Zc3h13 Zinc finger CCCH domain-containing protein 1314685.38
Unknown Gm1568 Gene model 156829884.28
Transcriptional regulation Atn1 Atrophin-1 61884.00
Unknown Dact3 Dapper homolog 3a27482.46
Unknown Hdgfrp2 Hepatoma-derived growth factor-related protein 232282.45
Cytoskeletal Synpo Synaptopodin14982.35
Cytoskeletal Mapt Microtubule-associated protein Tau23581.01
Cytoskeletal MAP4 Microtubule-associated protein 435780.71
Unknown Otud4 Otud46079.78
Transcriptional regulation Ncor2 Nuclear receptor corepressor 2a23479.17
Unknown Als2cr13 Amyotrophic lateral sclerosis 2 chromosome region, candidate 13a17079.11
Splicing/RNA binding Sf1 Splicing factor 129178.41
Splicing/RNA binding PPIG Peptidyl-prolyl cis-trans isomerase G51677.19
Unknown Glcci1 Glucocorticoid-induced transcript 1 protein16877.09
UnknownA830010M20RikHypothetical ATP/GTP-binding site motif A-containing protein16676.57
Translational regulation Atxn2 Ataxin-2 12376.26
Splicing/RNA binding Sfrs4 Splicing factor, arginine/serine-rich 433476.07
Unknown Specc1 Sperm antigen with calponin homology and coiled-coil domains 1a19475.35
Splicing/RNA binding Sfrs11 Splicing factor, arginine/serine-rich 11 homolog16575.35
Cytoskeletal Map1a Microtubule-associated protein 1A20075.29
Unknown Phldb1 Pleckstrin homology-like domain family B member 135873.52
Transcriptional regulation Gatad2b Transcriptional repressor p66β15173.40
G-protein modulator Ralbp1 RalA-binding protein 122973.26
Splicing/RNA binding YTHDC1 YTH domain-containing protein 122673.18
Splicing/RNA binding Zranb2 Zinc finger protein 26515573.13
Translational regulation Atxn1 Ataxin-1 15673.11
Unknown Kiaa0284 Kiaa0284 proteina13271.92
  • a Six phosphoproteins identified in the dephosphorylation experiment only.