Table III

Proteins reacting with autoantibodies associated to colorectal cancer

Proteins were classified according to the calculated p values and to the prevalence of the protein in the CRC or control groups.

NameCancer prevalenceControl prevalencep valueFunction
%%
Increased reactivity in colorectal cancer
    MAPKAPK371.4100.0099Ras protein signal transduction
    PIM171.4200.0099Cell proliferation
    STK471.4200.0099Cell morphogenesis
    FGFR471.4200.0099Fibroblast growth factor receptor signaling pathway
    TRIM2171.4200.0099Transcription regulation
    SRC57.1100.0102Ras protein signal transduction
    AKT157.1100.0102G-protein-coupled receptor protein signaling pathway
    KDR57.1100.0102Angiogenesis
    PKN157.1100.0102Activation of JNK activity
    CSNK1G292.9500.0144Wnt receptor signaling pathway
    DAPK192.9500.0144Antiapoptosis
    PBK78.6300.0154Mitosis
    NEK385.7300.0181Cell cycle
    PRKCD85.7400.0181Intracellular signaling cascade
    SALL250.0100.0238Regulation of transcription, DNA-dependent
    GRK750.0100.0238G-protein-coupled receptor kinase 1 activity
    IRAK450.0100.0238I-κB kinase/NF-κB cascade
    MAPKAPK550.0100.0238Ras protein signal transduction
    PKN250.0100.0238Signal transduction
    ABL250.0100.0238Cell adhesion
    RPS6KA164.3100.0249Signal transduction
    BMX64.3200.0249Intracellular signaling cascade
    PDGFRB64.3200.0249Platelet-derived growth factor receptor signaling pathway
    CDK5/p3564.3200.0249Acetylcholine receptor signaling, muscarinic pathway
    RPS6KA271.4300.0399Signal transduction
Control prevalenceCancer prevalence
%%
Lower reactivity in colorectal cancer
    RBPJ607.10.0036DNA recombination
    ITGA68028.60.0099Cell adhesion
    ACVR2B7021.40.0144BMP signaling pathway
    NFYA507.10.0144Transcriptional regulation
    TTLL7507.10.0144Cell differentiation
    C9orf43507.10.0144Unknown
    ZNF706507.10.0144Unknown
    HDAC1507.10.0144Antiapoptosis
    TPM4507.10.0144Cell motility
    TSLP7021.40.0154Cytokine, cell signaling
    WBP27021.40.0154Unknown
    STAU16014.30.0181RNA-binding protein
    PFDN56014.30.0181Protein folding
    COASY6014.30.0181Biosynthesis of coenzyme A
    IGLC18035.70.0249tRNA aminoacylation for protein translation
    MFAP27021.40.0399Cytoskeleton
    BHMT27021.40.0399Methyltransferase
    EFNA37028.60.0399Cell-cell signaling