Table II

Panel of 52 candidate ovarian cancer biomarkers

COMP, cartilage oligomeric matrix protein; EGF, epidermal growth factor; GM2, GalNAcβ1→4(NeuAcα2→ 3)Galβ1→4Glcβ1-1′Cer.

Protein nameaMolecular mass
Da
AGRN, agrin precursor214,820
BCAM, Lutheran blood group glycoprotein precursor61,042
C14orf141; LTBP2, latent transforming growth factor β-binding protein 2 precursor195,039
CD248, isoform 1 of endosialin precursor80,840
CD59, CD59 glycoprotein precursor14,159
CLU, clusterin precursor52,477
COMP 80-kDa protein79,676
CPA4, carboxypeptidase A4 precursor47,334
CST3, cystatin-C precursor15,781
CST6, cystatin-M precursor16,493
CTGF, isoform 1 of connective tissue growth factor precursor38,073
DAG1, dystroglycan precursor97,563
DKK3, Dickkopf-related protein 3 precursor38,272
DSC2, isoform 2A of desmocollin-2 precursor99,945
DSG2, desmoglein 2 preproprotein122,276
ECM1, extracellular matrix protein 1 precursor60,655
EFEMP1, isoform 1 of EGF-containing fibulin-like extracellular matrix protein 1 precursor54,621
FAM3C, protein FAM3C precursor24,663
FBLN1, isoform C of fibulin-1 precursor74,442
FOLR1, folate receptor α precursor29,801
FSTL1, follistatin-related protein 1 precursor34,967
GLOD4, uncharacterized protein C17orf2554,995
GM2A, ganglioside GM2 activator precursor20,805
GPX3, glutathione peroxidase 3 precursor25,488
HSPG2, basement membrane-specific heparan sulfate proteoglycan core protein precursor468,788
HTRA1, serine protease HTRA1 precursor51,269
IGFBP2, insulin-like growth factor-binding protein 2 precursor35,119
IGFBP3, insulin-like growth factor-binding protein 3 precursor31,656
IGFBP4, insulin-like growth factor-binding protein 4 precursor27,916
IGFBP5, insulin-like growth factor-binding protein 5 precursor30,552
IGFBP6, insulin-like growth factor-binding protein 6 precursor25,304
IGFBP7, insulin-like growth factor-binding protein 7 precursor29,112
LRG1, leucine-rich α2-glycoprotein precursor38,162
MST1, hepatocyte growth factor-like protein precursor80,360
MXRA5, matrix-remodeling-associated protein 5 precursor (adlican)312,263
NID2, nidogen-2 precursor151,377
NPC2, epididymal secretory protein E1 precursor16,552
NUCB1, nucleobindin-1 precursor53,862
PCOLCE, procollagen C-endopeptidase enhancer 1 precursor47,955
PLEC1, isoform 1 of plectin-1531,708
PLTP, isoform 1 of phospholipid transfer protein precursor54,723
PROCR, endothelial protein C receptor precursor30,697
PROS1, vitamin K-dependent protein S precursor75,105
PSAP, isoform Sap-mu-0 of proactivator polypeptide precursor58,094
QSCN6, isoform 1 of sulfhydryl oxidase 1 precursor82,561
SECTM1, secreted and transmembrane protein 1 precursor27,021
SERPINA6, corticosteroid-binding globulin precursor45,124
SOD1 16-kDa protein (superoxide dismutase 1)16,104
SVEP1, polydom (Sel-Ob)390,478
TAGLN2; CCDC19, transgelin-222,374
TGFBI, transforming growth factor-β-induced protein ig-h3 precursor74,665
VASN, vasorin precursor71,696
  • a For protein IPI accession numbers, see supplemental Table 1.