Table II

Protein function for the sulfinic acid-containing peptides that showed a dose response to HNO

Swiss-Prot accession numberProteinFunction
P60709Actin, cytoplasmic 1Cytoskeletal structure and cell mobility
Q01518 Adenylyl cyclase-associated protein 1Actin-binding protein; directly regulates filament dynamics
P06733 α-EnolaseMultifunctional enzyme that functions in glycolysis as well as growth control, hypoxia tolerance, and allergic responses
P04075 Fructose-bisphosphate aldolase AGlycolytic enzyme
P06396 Gelsolin precursorCalcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments
P04406 Glyceraldehyde-3-phosphate dehydrogenaseGlycolytic enzyme, also involved in membrane trafficking in the early secretory pathway
P05106 Integrin β3 precursorIntegrin αIIb/β3 primary ligand is fibrinogen; following activation integrin αIIb/β3 brings about platelet/platelet interaction through binding of soluble fibrinogen leading to platelet aggregation
P07359 Platelet glycoprotein 1b α chain precursorGP-Ib, a platelet surface membrane protein, participates in the formation of platelet plugs by binding to the A1 domain of von Willebrand factor
P14618 Pyruvate kinase isozymes M1/M2Glycolytic enzyme
P18206 VinculinInvolved in cell adhesion; may be involved in the attachment of the actin-based microfilaments to the plasma membrane