Table I

AUCs for diagnosing clinically significant fibrosis (F2–F4) determined using the DANA index

DANA is a method to model a uniform fibrosis stage prevalence in a study cohort with a skewed fibrosis distribution and can be used to compare the AUCs of biomarkers from different studies.

BiomarkersAUC (≥F2)
GlycoFibroTest0.75
α2-Macroglobulin0.78
log(hyaluronate)0.78
FibroTest0.83
Binary logistic regression model (α2-macroglobulin + GlycoFibroTest)0.84