Table I CEP markers in AMD and control plasma

CEP adduct concentration and autoantibody titer were determined by ELISA. Odds ratios reflect the AMD risk for donors exhibiting elevated levels of both CEP markers relative to median control levels (≥19 pmol/ml CEP adducts and ≥1.3 CEP autoantibody titer). p values were determined using the Fisher exact test. AMD categories are based on the Age-Related Eye Disease Study classification system (2). Odds ratios, 95% CI, and p values are based on log-transformed CEP marker concentrations. Ab, antibody.

nCEP adductCEP auto-Ab titer (A/A0)Both CEP adduct and auto-Ab elevated
Mean ± S.D.Median (Q1, Q3)Mean ± S.D.Median (Q1, Q3)Odds ratio95% CIp value
pmol/ml
Control48823 ± 1519 (14, 29)1.5 ± 1.01.3 (0.8, 1.9)1.00Reference
All AMD91637 ± 2033 (23, 46)2.0 ± 1.31.6 (1.1, 2.5)3.172.51, 4.02<0.001
AMD category 217735 ± 1931 (22, 46)2.2 ± 1.31.8 (1.3, 2.6)4.242.95, 6.10<0.001
AMD category 313032 ± 1728 (20, 39)2.2 ± 1.41.7 (1.2, 2.8)3.252.18, 4.84<0.001
AMD category 460939 ± 2134 (24, 48)1.9 ± 1.21.5 (1.0, 2.3)2.912.26, 3.75<0.001